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Vacation rentals in Panama Canal

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Panama Canal

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite
Apartment in Panamá
4.93 out of 5 average rating, 57 reviews

Estilo colonial con calicanto y balcón privado

Bienvenidos a un apartamento acogedor donde el encanto de las paredes de calicanto se mezcla con detalles cálidos y un balcón perfecto para disfrutar del ambiente y la vista del Casco Antiguo. Tenemos una ubicación privilegiada en una de las principales avenidas del Casco, desde aquí podrás acceder fácilmente a sitios históricos, restaurantes, cafés, bares y rincones llenos de encanto. La idea es que llegues, te sientas cómodo, disfrutes la ciudad a tu ritmo, ya sea solo, en pareja o en familia.

Top guest favourite
Place to stay in Panamá
5 out of 5 average rating, 23 reviews

Casa Condal - Your Luxury Retreat in Cerro Azul

Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

Top guest favourite
A charming apartment building is nestled among lush greenery and tall trees. The exterior features a welcoming porch with railings and is surrounded by tropical plants, creating a serene environment. Natural sunlight filters through the leaves, highlighting the vibrant foliage.
Guesthouse in Gamboa
4.94 out of 5 average rating, 86 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Superhost
An indoor garden is showcased, featuring lush greenery and soft lighting. A glass roof allows natural light to illuminate the space, which is accented by warm-toned stone walls. Two stylish chairs are positioned nearby, creating a comfortable seating area.
Condo in Panamá
4.88 out of 5 average rating, 149 reviews

CASA SAEMA -PRESTIGIOSO ATICO DUPLEX CON TERRAZAS

Espectacular ático Duplex en Panamá Casco antiguo, de 265 M2 con balcones, terrazas privadas exterior, cuenta con una salón jardín interior, un comedor, 3 hab. (+ sofá cama en studio), recientemente reformado con concepto Loft, diseño exclusivo único y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina , lavavajilla, sala con lavadora. piscina compartida, asc, portero 24-7, no se permiten niños que no sepan nadar, gran variedad de ocio en la zona.

Guest favourite
Apartment in Panamá
4.96 out of 5 average rating, 258 reviews

En el corazón de Casco, remodelado y con parking

Escápate y descubre casco antiguo en este remodelado , cómodo y céntrico alojamiento en el corazón de Casco Viejo. Nuestra ubicación es lo mejor, te hará regresar. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. La propiedad data del siglo XVII (1756) historia y buen ambiente. Podrás explorar la zona a pie, cocina full equipada, cama king europea, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar -Cocina full equipada

Top guest favourite
Apartment in Panama City
4.98 out of 5 average rating, 127 reviews

The View of Casco: Designer Loft with best Balcony

Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! ​Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. ​You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Guest favourite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in Panamá
4.93 out of 5 average rating, 123 reviews

Loft 3b Casco Antiguo Best! Son 150 m2 (492 feet)

Sumérgete en el encanto histórico y la elegancia moderna de nuestro loft de 3 recámaras y 150 m2, en el corazón del Casco Antiguo. Con pisos de madera que irradian calidez y una cocina moderna de diseño abierto ideal para compartir, este espacio garantiza unas vacaciones memorables. Situado en la Avenida A, te encontrarás a solo unos pasos de exquisitos restaurantes, museos, iglesias coloniales y los codiciados rooftops del Casco, convirtiendo cada día en una aventura.

Top guest favourite
Apartment in Panamá
4.97 out of 5 average rating, 36 reviews

Walk to Everything | Luxury Stay in Casco Viej

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Top guest favourite
Apartment in Panamá
4.94 out of 5 average rating, 70 reviews

Gorgeous Flat in the best location in Casco Viejo

This cute and stylish studio is perfectly located in the heart of Casco Viejo, Panama City’s most charming historic district. Recently renovated, it combines modern comfort with classic charm inside a beautiful colonial building—just steps from top restaurants, bars, monuments, and attractions. The space includes a comfortable sofa bed, making it ideal for a couple or a small family looking to enjoy the vibrant atmosphere of Casco right outside their door.

Top guest favourite
Apartment in Panamá
5 out of 5 average rating, 37 reviews

Private parking & rooftop | Studio Casco Center

This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Top guest favourite
Apartment in Panamá
5 out of 5 average rating, 32 reviews

Most Beautiful Loft in the Heart of Casco Viejo

Discover Casco Viejo from this beautiful loft, perfectly located. Casco Viejo, UNESCO World Heritage Site, known for its colonial buildings, and iconic streets. This vibrant neighborhood offers many restaurants, coffee places, museums, and an exciting night life. Just steps from Fonda Lo Que Hay, ranked among Latin America's Top 50 culinary destinations. Close to MYKA Greek Yogurt and the iconic La Compañía Hotel.

Guest favourite
Home in Gamboa
4.86 out of 5 average rating, 111 reviews

BirdHouse — Gamboa, Panama Canal Rainforest

BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.

Popular amenities for Panama Canal vacation rentals