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Apartment vacation rentals in Panama

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Top-rated apartment rentals in Panama

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Guest favourite
Apartment in Panamá
4.96 out of 5 average rating, 258 reviews

In the heart of Casco, renovated and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Guest favourite
A historic building with a prominent tower features elegant architecture, complemented by lush greenery in the foreground. Nearby palms and flowering trees create a serene environment, while the sky offers soft blue tones, enhancing the overall ambiance of the vibrant Casco Antiguo area.
Apartment in Panama City
4.81 out of 5 average rating, 139 reviews

Best Location – Fancy Apartment in Casco Viejo

Experience absolute luxury in our fully remodeled loft, with access to a spectacular 360° rooftop terrace, where you'll enjoy breathtaking views of the city and skyline. The building also features an elevator for your convenience. Located right in front of a vibrant plaza with renowned restaurants, the location is truly unbeatable, and security in the area is excellent. Relax in the rooftop, enjoy sunset views from the terrace, and experience the unique charm of Panama’s historic Casco Antiguo

Superhost
Apartment in Panamá
4.92 out of 5 average rating, 168 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Top guest favourite
A comfortable seating area features a wooden couch adorned with light-colored pillows. Large windows provide a view of the lush greenery outside, while a warm light fixture adds a soft glow to the room. The space is complemented by a simple wooden table and concrete flooring.
Apartment in Provincia de Veraguas
4.93 out of 5 average rating, 134 reviews

Casa Melina Torio Cozy upscale 2b jungle apartment

Stylish jungle two bedroom apartment Walking distance 5 restaurants. attractions: waterfall, jungle trails, River, Beach & Morrillo Surf break. Fully equipped with everything you need & want (Drinking water filter, Hot water, AC, Starlink WiFi & TV). Perfect for a couple/family seeking to blend work and play. Designed so our guests can fully experience our Torio culture. Cook with local fresh ingredients, discover Torio on foot & return to rest in the coziest rental you have ever experienced.

Guest favourite
A spacious terrace features four hammocks suspended between columns, inviting relaxation with a view of the serene ocean. A dining table with surrounding chairs is positioned nearby, overlooking calm waters and lush greenery, enhancing the outdoor living experience.
Apartment in Juan Gallego
4.88 out of 5 average rating, 221 reviews

Pebos Reef Apt 1 · Beachfront · Sea View Terrace

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Top guest favourite
Apartment in Panama City
4.98 out of 5 average rating, 127 reviews

The View of Casco: Designer Loft with best Balcony

Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! ​Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. ​You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Top guest favourite
Apartment in Panamá
4.97 out of 5 average rating, 36 reviews

Walk to Everything | Luxury Stay in Casco Viej

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Guest favourite
Apartment in Panamá
4.93 out of 5 average rating, 57 reviews

Colonial style with calicanto and a private balcony

Welcome to a cozy apartment where the charm of the calicanto walls blends with warm details and a perfect balcony to enjoy the atmosphere and the view of the Old Town. We are in a prime location on one of the main avenues of Casco. From here, you can easily access historical sites, restaurants, cafes, bars, and charming spots. The idea is that you arrive, feel comfortable, and enjoy the city at your own pace, whether alone, as a couple, or with your family.

Top guest favourite
An expansive infinity pool reflects the skyline of Panama City and the nearby bay. Lounge chairs are arranged neatly along the poolside, allowing for relaxation while enjoying the panoramic views of the surrounding area.
Apartment in Panama City
4.92 out of 5 average rating, 133 reviews

Impressive ocean and Panama City views

Enjoy a unique experience, a modern apartment with its own style, where every sunrise and sunset becomes a show. Enjoy breathtaking views of Panama City, the bay, and the Old Town from the comfort of your home. Unbeatable Location Located just 5 minutes from the charming Casco Viejo and the famous seafood market, and 10 minutes from the banking area. In addition, you will have a metro station and several bus stops just a few steps from the building

Guest favourite
Apartment in Panamá
4.89 out of 5 average rating, 101 reviews

Modern, central and comfortable (104)

Moderno y acogedor estudio en el corazón de Panamá. Perfecto para explorar el Casco Antiguo, la Cinta Costera y más. Cocina completa, cama queen, sofá cama doble, aire acondicionado, WiFi rápido y baño privado. Ideal para 1–4 personas. Acceso privado, ascensor y check-in autónomo. Rodeado de restaurantes, transporte y sitios turísticos. ¡Tu base ideal para conocer la ciudad! 🧳 Estancias largas bienvenidas (descuentos aplicables)

Guest favourite
A cozy sitting area is highlighted by a large window offering views of the vibrant plaza and cathedral. Two comfortable armchairs are positioned beside a small coffee table on a textured rug. Natural light fills the space, enhancing the warm tones of the wooden floor.
Apartment in Panama City
4.91 out of 5 average rating, 124 reviews

The best view of the Old Town

Welcome to this charming accommodation in the heart of the Casco Viejo, located on the third floor facing one of Panama's most iconic squares, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Guest favourite
Apartment in Panamá
4.98 out of 5 average rating, 160 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Popular amenities for Panama apartment rentals