
Apartment vacation rentals in Panama City
Find and book unique apartments on Airbnb
Quick stats about apartment rentals in Panama City

Total vacation rentals
Explore 3,150 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at $14 CAD per night before taxes and fees

Verified guest reviews
Over 97,220 verified reviews to help you choose

Family-friendly vacation rentals
1,010 properties offer extra space and kid-friendly amenities

Pet-friendly vacation rentals
Find 1,180 rentals that welcome pets

Vacation rentals with a pool
2,170 properties feature pools

Rentals with dedicated workspaces
2,060 properties have a dedicated workspace

Wifi availability
3,090 of Panama City vacation rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City’s top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated apartment rentals in Panama City
Guests agree: these apartments are highly rated for location, cleanliness, and more.

In the heart of Casco, renovated and with parking
Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Best Location – Fancy Apartment in Casco Viejo
Experience absolute luxury in our fully remodeled loft, with access to a spectacular 360° rooftop terrace, where you'll enjoy breathtaking views of the city and skyline. The building also features an elevator for your convenience. Located right in front of a vibrant plaza with renowned restaurants, the location is truly unbeatable, and security in the area is excellent. Relax in the rooftop, enjoy sunset views from the terrace, and experience the unique charm of Panama’s historic Casco Antiguo

Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

The View of Casco: Designer Loft with best Balcony
Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Ocean View Apt in Panama, Yoo&Arts
Iconic luxury at Yoo&Arts Panama. This spectacular 130m² (1,400 sq ft) apartment offers sophisticated design and a breathtaking panoramic view of the Pacific Ocean. Enjoy breakfast on the balcony with an exceptional breeze, watch the sunrise from your bedroom, or work in an inspiring environment. Located on Avenida Balboa, the city's most exclusive area, you’ll have direct access to fine dining inside the building, premium supermarkets, and shopping malls nearby.

Walk to Everything | Luxury Stay in Casco Viej
Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Impressive ocean and Panama City views
Enjoy a unique experience, a modern apartment with its own style, where every sunrise and sunset becomes a show. Enjoy breathtaking views of Panama City, the bay, and the Old Town from the comfort of your home. Unbeatable Location Located just 5 minutes from the charming Casco Viejo and the famous seafood market, and 10 minutes from the banking area. In addition, you will have a metro station and several bus stops just a few steps from the building

Studio apartment in the heart of Casco
Welcome to Casa Pérez, your retreat in the heart of the Old Town! Enjoy a prime location and the best views from a spectacular private balcony facing the most iconic square in the Casco. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, washing machine and elevator for your comfort. Enjoy an unforgettable stay in a warm and fully equipped atmosphere.

Modern, central and comfortable (104)
Moderno y acogedor estudio en el corazón de Panamá. Perfecto para explorar el Casco Antiguo, la Cinta Costera y más. Cocina completa, cama queen, sofá cama doble, aire acondicionado, WiFi rápido y baño privado. Ideal para 1–4 personas. Acceso privado, ascensor y check-in autónomo. Rodeado de restaurantes, transporte y sitios turísticos. ¡Tu base ideal para conocer la ciudad! 🧳 Estancias largas bienvenidas (descuentos aplicables)

Spectacular views, a pool, and an ideal location
Disfruta una experiencia inolvidable en una ubicación privilegiada de Ciudad de Panama. Despierta con impresionantes vistas de los edificios, el mar. Relajate en la piscina o el rooftop y siéntete como en casa gracias a nuestra hospitalidad. A pocos minutos del Casco Antiguo, Cinta Costera, Metro, Restaurantes, bares y centros comerciales, Albrook Mall, Multiplaza Mall, Soho Mall. Ideal para vacaciones o viajes de negocios.

The best view of the Old Town
Welcome to this charming accommodation in the heart of the Casco Viejo, located on the third floor facing one of Panama's most iconic squares, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Most Beautiful Loft in the Heart of Casco Viejo

Luxury Centric 2BR Apartment in Casco Viejo

Private parking & rooftop | Studio Casco Center

Luxury apt in Panama City 2 Rooms 3 Baths

Luxury Apartment | Walk to Restaurants & Shops

La Fontana Spacious ApartaSuite - Pool 102

Colonial style with calicanto and a private balcony

Panoramic Casco Viejo Lookout in The Sands
Private apartment rentals

Suite Luxury 30th View Yoo Panamá & Arts Tower

Warm and cozy facing the sea

Lovely & Cozy central apartment in Casco Viejo

Unique Luxury 3-story Loft at the Yoo

Ocean View Suite Coastal Strip

VIP Suite/Sea View + Pool & Sky Lounge + Gym

Tropicool Casco Loft w/King Bed & Rooftop

Poin Avenida Balboa, Panama City
Apartment rentals with a hot tub

Historic 2BR Loft at Casa del Horno, Old Town

Luxury 2BR Suite with Pool & Views

Lovely apartment with Jacuzzi "Senses House"

New Flat with Ocean + City Views

Tropical Paradise at Playa Bonita

Ocean View | Infinity pool | Balbia Ave Apt

2BR King Suite Ocean View, Casco, Canal 500MB WIFI

PH The Gray | Balcony Views · Pool · Gym
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- Things to do Panama
- Landmarks Panama
- Water sports Panama
- Nature and outdoors Panama
- Food tours Panama
- Sports activities Panama
- Tastings Panama
- Sightseeing Panama
- Wildlife Panama
- Outdoors Panama
- Cultural tours Panama
- Tours Panama
- Food and drink Panama
- Art and culture Panama
- Cooking Panama





